A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation

Epidermal growth factor receptor (EGFR) activation by growth factors (GFs) relies on dimerization and allosteric activation of its intrinsic kinase activity, resulting in trans-phosphorylation of tyrosines on its C-terminal tail. While structural and biochemical studies identified this EGF-induced a...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Baumdick, Martin, Gelléri, Márton, Uttamapinant, Chayasith, Beránek, Václav, Chin, Jason W., Bastiaens, Philippe I. H.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155120/
https://ncbi.nlm.nih.gov/pubmed/30242154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06299-7
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