A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation

Epidermal growth factor receptor (EGFR) activation by growth factors (GFs) relies on dimerization and allosteric activation of its intrinsic kinase activity, resulting in trans-phosphorylation of tyrosines on its C-terminal tail. While structural and biochemical studies identified this EGF-induced a...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Baumdick, Martin, Gelléri, Márton, Uttamapinant, Chayasith, Beránek, Václav, Chin, Jason W., Bastiaens, Philippe I. H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155120/
https://ncbi.nlm.nih.gov/pubmed/30242154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06299-7
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