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EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling
Autocatalytic activation of epidermal growth factor receptor (EGFR) coupled to dephosphorylating activity of protein tyrosine phosphatases (PTPs) ensures robust yet diverse responses to extracellular stimuli. The inevitable tradeoff of this plasticity is spontaneous receptor activation and spurious...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4716840/ https://ncbi.nlm.nih.gov/pubmed/26609808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12223 |
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