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EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling
Autocatalytic activation of epidermal growth factor receptor (EGFR) coupled to dephosphorylating activity of protein tyrosine phosphatases (PTPs) ensures robust yet diverse responses to extracellular stimuli. The inevitable tradeoff of this plasticity is spontaneous receptor activation and spurious...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4716840/ https://ncbi.nlm.nih.gov/pubmed/26609808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12223 |
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