Interdependence between EGFR and Phosphatases Spatially Established by Vesicular Dynamics Generates a Growth Factor Sensing and Responding Network

The proto-oncogenic epidermal growth factor receptor (EGFR) is a tyrosine kinase whose sensitivity to growth factors and signal duration determines cellular behavior. We resolve how EGFR's response to epidermal growth factor (EGF) originates from dynamically established recursive interactions w...

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Publicado en:Cell Syst
Main Authors: Stanoev, Angel, Mhamane, Amit, Schuermann, Klaus C., Grecco, Hernán E., Stallaert, Wayne, Baumdick, Martin, Brüggemann, Yannick, Joshi, Maitreyi S., Roda-Navarro, Pedro, Fengler, Sven, Stockert, Rabea, Roßmannek, Lisaweta, Luig, Jutta, Koseska, Aneta, Bastiaens, Philippe I.H.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6167251/
https://ncbi.nlm.nih.gov/pubmed/30145116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2018.06.006
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