Molecular basis for activation and biased signaling at the thrombin-activated GPCR proteinase activated receptor-4 (PAR4)

Proteinase-activated receptor (PAR)-4 is a member of the proteolytically-activated PAR family of G-protein–coupled receptors (GPCR) that represents an important target in the development of anti-platelet therapeutics. PARs are activated by proteolytic cleavage of their receptor N terminus by enzymes...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Thibeault, Pierre E., LeSarge, Jordan C., Arends, D'Arcy, Fernandes, Michaela, Chidiac, Peter, Stathopulos, Peter B., Luyt, Leonard G., Ramachandran, Rithwik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039573/
https://ncbi.nlm.nih.gov/pubmed/31892516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011461
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