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Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain
Glucose homeostasis and growth essentially depend on the hormone insulin engaging its receptor. Despite biochemical and structural advances, a fundamental contradiction has persisted in the current understanding of insulin ligand–receptor interactions. While biochemistry predicts two distinct insuli...
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| Veröffentlicht in: | J Cell Biol |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Rockefeller University Press
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7039211/ https://ncbi.nlm.nih.gov/pubmed/31727777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201907210 |
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