Synergistic Activity of Exebacase (CF-301) in Addition to Daptomycin against Staphylococcus aureus in a Neutropenic Murine Thigh Infection Model

We evaluated the efficacy of escalating doses of exebacase administered with subtherapeutic daptomycin exposures against 8 Staphylococcus aureus isolates in a neutropenic murine thigh infection model. Daptomycin alone resulted in mean growth of 0.39 ± 1.19 log(10) CFU/thigh. When administered with d...

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Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Asempa, Tomefa E., Abdelraouf, Kamilia, Carabeo, Teresa, Schuch, Raymond, Nicolau, David P.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2020
Предметы:
Experimental Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038299/
https://ncbi.nlm.nih.gov/pubmed/31818816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02176-19
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