Exebacase in Addition to Daptomycin Is More Active than Daptomycin or Exebacase Alone in Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats

Bacteriophage-derived lysins are being developed as anti-infective agents. In an acute osteomyelitis methicillin-resistant Staphylococcus aureus (MRSA) model, rats receiving no treatment or treatment with daptomycin, exebacase (CF-301), or daptomycin plus exebacase had means of 5.13, 4.09, 4.65, and...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Karau, Melissa J., Schmidt-Malan, Suzannah M., Yan, Qun, Greenwood-Quaintance, Kerryl E., Mandrekar, Jayawant, Lehoux, Dario, Schuch, Raymond, Cassino, Cara, Patel, Robin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761499/
https://ncbi.nlm.nih.gov/pubmed/31358593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01235-19
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