Identification and clinical impact of potentially actionable somatic oncogenic mutations in solid tumor samples

BACKGROUND: An increasing number of anti-cancer therapeutic agents target specific mutant proteins that are expressed by many different tumor types. Successful use of these therapies is dependent on the presence or absence of somatic mutations within the patient’s tumor that can confer clinical effi...

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Bibliografiske detaljer
Udgivet i:J Transl Med
Main Authors: Toomey, Sinead, Carr, Aoife, Mezynski, Mateusz Janusz, Elamin, Yasir, Rafee, Shereen, Cremona, Mattia, Morgan, Clare, Madden, Stephen, Abdul-Jalil, Khairun I., Gately, Kathy, Farrelly, Angela, Kay, Elaine W., Kennedy, Susan, O’Byrne, Kenneth, Grogan, Liam, Breathnach, Oscar, Morris, Patrick G., Eustace, Alexander J., Fay, Joanna, Cummins, Robert, O’Grady, Anthony, Kalachand, Roshni, O’Donovan, Norma, Kelleher, Fergal, O’Reilly, Aine, Doherty, Mark, Crown, John, Hennessy, Bryan T.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7036178/
https://ncbi.nlm.nih.gov/pubmed/32087721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02273-4
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