Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer

OBJECTIVE: The therapeutic benefits of poly(ADP-ribose) polymerase inhibitors highlight the need to evaluate BRCA1/2 defects in tubal/ovarian cancer (OC). We sought to determine the pattern and disease characteristics associated with tumor BRCA1/2 mutations and BRCA1 methylation in women with OC. ME...

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Detalhes bibliográficos
Publicado no:Obstet Gynecol Sci
Main Authors: Kalachand, Roshni D., O’Riain, Ciaran, Toomey, Sinead, Carr, Aoife, Timms, Kirsten M., O’Toole, Sharon, Madden, Stephen, Bates, Mark, O’Leary, John J., Gleeson, Noreen, O’Donnell, Dearbhaile, Grogan, Liam, Breathnach, Oscar, Farrelly, Angela, Stordal, Britta, Hennessy, Bryan T.
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society of Obstetrics and Gynecology 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494761/
https://ncbi.nlm.nih.gov/pubmed/32872764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5468/ogs.20033
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