Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer

PURPOSE: To investigate the incidence of germline and somatic BRCA1/2 mutations in unselected patients with triple negative breast cancer (TNBC), and determine the prognostic significance of carrying a mutation. METHODS: DNA was obtained from 77 TNBC and normal tissues. BRCA1/2 exons/flanking region...

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Main Authors: Gonzalez-Angulo, Ana M., Timms, Kirsten M., Liu, Shuying, Chen, Huiqin, Litton, Jennifer K., Potter, Jennifer, Lanchbury, Jerry S., Stemke-Hale, Katherine, Hennessy, Bryan T., Arun, Banu K., Hortobagyi, Gabriel N., Do, Kim-Anh, Mills, Gordon B., Meric-Bernstam, Funda
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048924/
https://ncbi.nlm.nih.gov/pubmed/21233401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2560
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