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Heat-triggered remote control of CRISPR-dCas9 for tunable transcriptional modulation
CRISPR-associated proteins (Cas) are enabling powerful new approaches to control mammalian cell functions, yet the lack of spatially defined, noninvasive modalities limit their use as biological tools. Here, we integrate thermal gene switches with dCas9 complexes to confer remote control of gene act...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7035993/ https://ncbi.nlm.nih.gov/pubmed/31904924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b01005 |
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