Antitubercular Triazines: Optimization and Intrabacterial Metabolism

The triazine antitubercular JSF-2019 was of interest due to its in vitro efficacy and the nitro group shared with the clinically relevant delamanid and pretomanid. JSF-2019 undergoes activation requiring F(420)H(2) and one or more nitroreductases in addition to Ddn. An intrabacterial drug metabolism...

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Detaylı Bibliyografya
Yayımlandı:Cell Chem Biol
Asıl Yazarlar: Wang, Xin, Inoyama, Daigo, Russo, Riccardo, Li, Shao-Gang, Jadhav, Ravindra, Stratton, Thomas P., Mittal, Nisha, Bilotta, Joseph A., Singleton, Eric, Kim, Thomas, Paget, Steve D., Pottorf, Richard S., Ahn, Yong-Mo, Davila-Pagan, Alejandro, Kandasamy, Srinivasan, Grady, Courtney, Hussain, Seema, Soteropoulos, Patricia, Zimmerman, Matthew D., Ho, Hsin Pin, Park, Steven, Dartois, Véronique, Ekins, Sean, Connell, Nancy, Kumar, Pradeep, Freundlich, Joel S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035970/
https://ncbi.nlm.nih.gov/pubmed/31711854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.10.010
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