Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release

Synaptotagmin 1 (Syt1) synchronizes neurotransmitter release to action potentials (APs) acting as the fast Ca(2+) release sensor and as the inhibitor (clamp) of spontaneous and delayed asynchronous release. While the Syt1 Ca(2+) activation mechanism has been well-characterized, how Syt1 clamps trans...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Tagliatti, Erica, Bello, Oscar D., Mendonça, Philipe R. F., Kotzadimitriou, Dimitrios, Nicholson, Elizabeth, Coleman, Jeff, Timofeeva, Yulia, Rothman, James E., Krishnakumar, Shyam S., Volynski, Kirill E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035618/
https://ncbi.nlm.nih.gov/pubmed/32015138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920403117
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