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Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release
Synaptotagmin 1 (Syt1) synchronizes neurotransmitter release to action potentials (APs) acting as the fast Ca(2+) release sensor and as the inhibitor (clamp) of spontaneous and delayed asynchronous release. While the Syt1 Ca(2+) activation mechanism has been well-characterized, how Syt1 clamps trans...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7035618/ https://ncbi.nlm.nih.gov/pubmed/32015138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920403117 |
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