Synaptotagmin oligomers are necessary and can be sufficient to form a Ca(2+)‐sensitive fusion clamp

The buttressed‐ring hypothesis, supported by recent cryo‐electron tomography analysis of docked synaptic‐like vesicles in neuroendocrine cells, postulates that prefusion SNAREpins are stabilized and organized by Synaptotagmin (Syt) ring‐like oligomers. Here, we use a reconstituted single‐vesicle fus...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:FEBS Lett
Main Authors: Ramakrishnan, Sathish, Bera, Manindra, Coleman, Jeff, Krishnakumar, Shyam S., Pincet, Frederic, Rothman, James E.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Research Letters
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349546/
https://ncbi.nlm.nih.gov/pubmed/30570144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.13317
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