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Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework
In Mendelian randomization (MR) analysis, variants that exert horizontal pleiotropy are typically treated as a nuisance. However, they could be valuable in identifying alternative pathways to the traits under investigation. Here, we develop MR-TRYX, a framework that exploits horizontal pleiotropy to...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7035387/ https://ncbi.nlm.nih.gov/pubmed/32081875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14452-4 |
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