Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease

We have undertaken a systematic Mendelian randomization (MR) study using methylation quantitative trait loci (meQTL) as genetic instruments to assess the relationship between genetic variation, DNA methylation and 139 complex traits. Using two-sample MR, we identified 1148 associations across 61 tra...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Richardson, Tom G, Haycock, Philip C, Zheng, Jie, Timpson, Nicholas J, Gaunt, Tom R, Davey Smith, George, Relton, Caroline L, Hemani, Gibran
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6121186/
https://ncbi.nlm.nih.gov/pubmed/29893838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy210
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