SPEN integrates transcriptional and epigenetic control of X-inactivation

Xist represents a paradigm for long non-coding RNA function in epigenetic regulation, although how it mediates X-chromosome inactivation (XCI) remains largely unexplained. Multiple Xist-RNA binding proteins have recently been identified, including SPEN(1–3), the loss of which has been associated wit...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Dossin, François, Pinheiro, Inês, Żylicz, Jan J., Roensch, Julia, Collombet, Samuel, Le Saux, Agnès, Chelmicki, Tomasz, Attia, Mikaël, Kapoor, Varun, Zhan, Ye, Dingli, Florent, Loew, Damarys, Mercher, Thomas, Dekker, Job, Heard, Edith
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035112/
https://ncbi.nlm.nih.gov/pubmed/32025035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-1974-9
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