Light-induced control of protein destruction by opto-PROTAC

By hijacking endogenous E3 ligase to degrade protein targets via the ubiquitin-proteasome system, PROTACs (PRoteolysis TArgeting Chimeras) provide a new strategy to inhibit protein targets that were regarded as undruggable before. However, the catalytic nature of PROTAC potentially leads to uncontro...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Liu, Jing, Chen, He, Ma, Leina, He, Zhixiang, Wang, Dong, Liu, Yi, Lin, Qian, Zhang, Tinghu, Gray, Nathanael, Kaniskan, H. Ümit, Jin, Jian, Wei, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034987/
https://ncbi.nlm.nih.gov/pubmed/32128407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay5154
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