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Cancer Selective Target Degradation by Folate-Caged PROTACs
PROTACs (proteolysis targeting chimeras) are an emerging class of promising therapeutic modalities that degrade intracellular protein targets by hijacking the cellular ubiquitin–proteasome system. However, potential toxicity of PROTACs in normal cells due to the off-tissue on-target degradation effe...
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| Veröffentlicht in: | J Am Chem Soc |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8219215/ https://ncbi.nlm.nih.gov/pubmed/33970635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.1c00451 |
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