Activation of the Kynurenine Pathway in Human Malignancies Can Be Suppressed by the Cyclin-Dependent Kinase Inhibitor Dinaciclib

Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO2) are the key enzymes of tryptophan (TRP) metabolism in the kynurenine pathway (KP). Both enzymes function as indicators of immunosuppression and poor survival in cancer patients. Direct or indirect targeting of either of these su...

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Pubblicato in:Front Immunol
Autori principali: Riess, Christin, Schneider, Björn, Kehnscherper, Hanna, Gesche, Julia, Irmscher, Nina, Shokraie, Fatemeh, Classen, Carl Friedrich, Wirthgen, Elisa, Domanska, Grazyna, Zimpfer, Annette, Strüder, Daniel, Junghanss, Christian, Maletzki, Claudia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034242/
https://ncbi.nlm.nih.gov/pubmed/32117235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00055
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