HGG-32. ARG-AUXOTROPHIC PATIENT-DERIVED GLIOBLASTOMA MULTIFORME CELL LINES SHOW INCREASED SENSITIVITY TOWARDS DOXYCYCLINE-INDUCED GROWTH INHIBITION

Arginine auxotrophy constitutes a metabolic defect that renders tumors susceptible towards arginine-depleting substances, such as bacterial arginine deiminase (ADI). In our previous studies, Arg auxotrophy and thus ADI-susceptibility was confirmed on patient-derived GBM models in vitro and in vivo....

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Publicado no:Neuro Oncol
Main Authors: Shokraie, Fatemeh, Riess, Christin, Fiedler, Tomas, Schneider, Björn, Classen, Carl Friedrich, Maletzki, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012856/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.304
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