Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health

Human but not mouse islets transplanted into immunodeficient NSG mice effectively accumulate lipid droplets (LDs). Because chronic lipid exposure is associated with islet β-cell dysfunction, we investigated LD accumulation in the intact human and mouse pancreas over a range of ages and states of dia...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Tong, Xin, Dai, Chunhua, Walker, John T., Nair, Gopika G., Kennedy, Arion, Carr, Rotonya M., Hebrok, Matthias, Powers, Alvin C., Stein, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2020
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034188/
https://ncbi.nlm.nih.gov/pubmed/31836690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0281
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