Insights into channel modulation mechanism of RYR1 mutants using Ca(2+) imaging and molecular dynamics

Type 1 ryanodine receptor (RYR1) is a Ca(2+) release channel in the sarcoplasmic reticulum in skeletal muscle and plays an important role in excitation–contraction coupling. Mutations in the RYR1 gene cause severe muscle diseases such as malignant hyperthermia (MH), which is a disorder of CICR via R...

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Veröffentlicht in:J Gen Physiol
Hauptverfasser: Yamazawa, Toshiko, Ogawa, Haruo, Murayama, Takashi, Yamaguchi, Maki, Oyamada, Hideto, Suzuki, Junji, Kurebayashi, Nagomi, Kanemaru, Kazunori, Oguchi, Katsuji, Sakurai, Takashi, Iino, Masamitsu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2019
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034096/
https://ncbi.nlm.nih.gov/pubmed/31841587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812235
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