Insights into channel modulation mechanism of RYR1 mutants using Ca(2+) imaging and molecular dynamics

Type 1 ryanodine receptor (RYR1) is a Ca(2+) release channel in the sarcoplasmic reticulum in skeletal muscle and plays an important role in excitation–contraction coupling. Mutations in the RYR1 gene cause severe muscle diseases such as malignant hyperthermia (MH), which is a disorder of CICR via R...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: Yamazawa, Toshiko, Ogawa, Haruo, Murayama, Takashi, Yamaguchi, Maki, Oyamada, Hideto, Suzuki, Junji, Kurebayashi, Nagomi, Kanemaru, Kazunori, Oguchi, Katsuji, Sakurai, Takashi, Iino, Masamitsu
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034096/
https://ncbi.nlm.nih.gov/pubmed/31841587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812235
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