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A tryptophan residue in the caffeine-binding site of the ryanodine receptor regulates Ca(2+) sensitivity
Ryanodine receptors (RyRs) are Ca(2+) release channels in the sarcoplasmic reticulum of skeletal and cardiac muscles and are essential for muscle contraction. Mutations in genes encoding RyRs cause various muscle and arrhythmogenic heart diseases. Although RyR channels are activated by Ca(2+), the a...
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| Publicat a: | Commun Biol |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6123685/ https://ncbi.nlm.nih.gov/pubmed/30271978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0103-x |
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