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A tryptophan residue in the caffeine-binding site of the ryanodine receptor regulates Ca(2+) sensitivity
Ryanodine receptors (RyRs) are Ca(2+) release channels in the sarcoplasmic reticulum of skeletal and cardiac muscles and are essential for muscle contraction. Mutations in genes encoding RyRs cause various muscle and arrhythmogenic heart diseases. Although RyR channels are activated by Ca(2+), the a...
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| Publicado en: | Commun Biol |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6123685/ https://ncbi.nlm.nih.gov/pubmed/30271978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0103-x |
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