Divergent Activity Profiles of Type 1 Ryanodine Receptor Channels Carrying Malignant Hyperthermia and Central Core Disease Mutations in the Amino-Terminal Region

The type 1 ryanodine receptor (RyR1) is a Ca(2+) release channel in the sarcoplasmic reticulum of skeletal muscle and is mutated in several diseases, including malignant hyperthermia (MH) and central core disease (CCD). Most MH and CCD mutations cause accelerated Ca(2+) release, resulting in abnorma...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Murayama, Takashi, Kurebayashi, Nagomi, Yamazawa, Toshiko, Oyamada, Hideto, Suzuki, Junji, Kanemaru, Kazunori, Oguchi, Katsuji, Iino, Masamitsu, Sakurai, Takashi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482644/
https://ncbi.nlm.nih.gov/pubmed/26115329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130606
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