Divergent Activity Profiles of Type 1 Ryanodine Receptor Channels Carrying Malignant Hyperthermia and Central Core Disease Mutations in the Amino-Terminal Region

The type 1 ryanodine receptor (RyR1) is a Ca(2+) release channel in the sarcoplasmic reticulum of skeletal muscle and is mutated in several diseases, including malignant hyperthermia (MH) and central core disease (CCD). Most MH and CCD mutations cause accelerated Ca(2+) release, resulting in abnorma...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Murayama, Takashi, Kurebayashi, Nagomi, Yamazawa, Toshiko, Oyamada, Hideto, Suzuki, Junji, Kanemaru, Kazunori, Oguchi, Katsuji, Iino, Masamitsu, Sakurai, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482644/
https://ncbi.nlm.nih.gov/pubmed/26115329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130606
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