Divergent Activity Profiles of Type 1 Ryanodine Receptor Channels Carrying Malignant Hyperthermia and Central Core Disease Mutations in the Amino-Terminal Region

The type 1 ryanodine receptor (RyR1) is a Ca(2+) release channel in the sarcoplasmic reticulum of skeletal muscle and is mutated in several diseases, including malignant hyperthermia (MH) and central core disease (CCD). Most MH and CCD mutations cause accelerated Ca(2+) release, resulting in abnorma...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Murayama, Takashi, Kurebayashi, Nagomi, Yamazawa, Toshiko, Oyamada, Hideto, Suzuki, Junji, Kanemaru, Kazunori, Oguchi, Katsuji, Iino, Masamitsu, Sakurai, Takashi
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482644/
https://ncbi.nlm.nih.gov/pubmed/26115329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130606
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