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Pumping the brakes on RAS – negative regulators and death effectors of RAS

Mutations that activate the RAS oncoproteins are common in cancer. However, aberrant upregulation of RAS activity often occurs in the absence of activating mutations in the RAS genes due to defects in RAS regulators. It is now clear that loss of function of Ras GTPase-activating proteins (RasGAPs) i...

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Bibliographic Details
Published in:J Cell Sci
Main Authors: Harrell Stewart, Desmond R., Clark, Geoffrey J.
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033738/
https://ncbi.nlm.nih.gov/pubmed/32041893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.238865
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