Protease activity in single-chain prekallikrein

Prekallikrein (PK) is the precursor of the trypsin-like plasma protease kallikrein (PKa), which cleaves kininogens to release bradykinin and converts the protease precursor factor XII (FXII) to the enzyme FXIIa. PK and FXII undergo reciprocal conversion to their active forms (PKa and FXIIa) by a pro...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Ivanov, Ivan, Verhamme, Ingrid M., Sun, Mao-fu, Mohammed, Bassem, Cheng, Qiufang, Matafonov, Anton, Dickeson, S. Kent, Joseph, Kusumam, Kaplan, Allen P., Gailani, David
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2020
Fag:
Thrombosis and Hemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033373/
https://ncbi.nlm.nih.gov/pubmed/31800958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002224
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