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Blocking IL-6/GP130 Signaling Inhibits Cell Viability/Proliferation, Glycolysis, and Colony Forming Activity in Human Pancreatic Cancer Cells

BACKGROUND: Elevated production of the pro-inflammatory cytokine interleukin-6 (IL-6) and dysfunction of IL-6 signaling promotes tumorigenesis and are associated with poor survival outcomes in multiple cancer types. Recent studies showed that the IL-6/GP130/STAT3 signaling pathway plays a pivotal ro...

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Bibliografiske detaljer
Udgivet i:Curr Cancer Drug Targets
Main Authors: Chen, Xiang, Tian, Jilai, Su, Gloria H., Lin, Jiayuh
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7032663/
https://ncbi.nlm.nih.gov/pubmed/29714141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1568009618666180430123939
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