Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery

The therapeutic potential of small nucleic acids such as small interfering RNA (siRNA) to treat lung diseases has been successfully demonstrated in many in vivo studies. A major barrier to their clinical application is the lack of a safe and efficient inhaled formulation. In this study, spray freeze...

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Vydáno v:Asian J Pharm Sci
Hlavní autoři: Liang, Wanling, Chan, Alan Y.L., Chow, Michael Y.T., Lo, Fiona F.K., Qiu, Yingshan, Kwok, Philip C.L., Lam, Jenny K.W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Shenyang Pharmaceutical University 2018
Témata:
Original Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7032260/
https://ncbi.nlm.nih.gov/pubmed/32104389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajps.2017.10.002
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