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Mechanics of Allostery: Contrasting the Induced Fit and Population Shift Scenarios

In allosteric proteins, binding a ligand can affect function at a distant location, for example, by changing the binding affinity of a substrate at the active site. The induced fit and population shift models, which differ by the assumed number of stable configurations, explain such cooperative bind...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biophys J
Hauptverfasser: Ravasio, Riccardo, Flatt, Solange Marie, Yan, Le, Zamuner, Stefano, Brito, Carolina, Wyart, Matthieu
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7031744/
https://ncbi.nlm.nih.gov/pubmed/31653447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.10.002
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