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Allostery and population shift in drug discovery

Proteins can exist in a large number of conformations around their native states that can be characterized by an energy landscape. The landscape illustrates individual valleys, which are the conformational substates. From the functional standpoint, there are two key points: first, all functionally r...

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Pubblicato in:Curr Opin Pharmacol
Autori principali: Kar, Gozde, Keskin, Ozlem, Gursoy, Attila, Nussinov, Ruth
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316380/
https://ncbi.nlm.nih.gov/pubmed/20884293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coph.2010.09.002
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