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A Strategy Based on Protein-Protein Interface Motifs May Help in Identifying Drug Off-Targets
Networks are increasingly used to study the impact of drugs at the systems level. From the algorithmic standpoint, a drug can ‘attack’ nodes or edges of a protein-protein interaction network. In this work, we propose a new network strategy, “The Interface Attack”, based on protein-protein interfaces...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3979525/ https://ncbi.nlm.nih.gov/pubmed/22817115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci300072q |
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