Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis

Photoreceptor cell death is the ultimate cause of vision loss in many retinal disorders, and there is an unmet need for neuroprotective modalities to improve photoreceptor survival. Similar to cancer cells, photoreceptors maintain pyruvate kinase muscle isoform 2 (PKM2) expression, which is a critic...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Wubben, Thomas J., Pawar, Mercy, Weh, Eric, Smith, Andrew, Sajjakulnukit, Peter, Zhang, Li, Dai, Lipeng, Hager, Heather, Pai, Manjunath P., Lyssiotis, Costas A., Besirli, Cagri G.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7031539/
https://ncbi.nlm.nih.gov/pubmed/32076076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59999-w
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars