Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis

Photoreceptor cell death is the ultimate cause of vision loss in many retinal disorders, and there is an unmet need for neuroprotective modalities to improve photoreceptor survival. Similar to cancer cells, photoreceptors maintain pyruvate kinase muscle isoform 2 (PKM2) expression, which is a critic...

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Pubblicato in:Sci Rep
Autori principali: Wubben, Thomas J., Pawar, Mercy, Weh, Eric, Smith, Andrew, Sajjakulnukit, Peter, Zhang, Li, Dai, Lipeng, Hager, Heather, Pai, Manjunath P., Lyssiotis, Costas A., Besirli, Cagri G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7031539/
https://ncbi.nlm.nih.gov/pubmed/32076076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59999-w
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