Amplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunity

Antigenic variation, the capacity to produce a range of variable antigens, is a well-described strategy of Plasmodium and other parasites to evade host immunity. Here, we show that gene amplification is an additional evasion mechanism used by Plasmodium vivax to escape humoral immunity targeting PvD...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Popovici, Jean, Roesch, Camille, Carias, Lenore L., Khim, Nimol, Kim, Saorin, Vantaux, Amelie, Mueller, Ivo, Chitnis, Chetan E., King, Christopher L., Witkowski, Benoit
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7031336/
https://ncbi.nlm.nih.gov/pubmed/32075983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14574-9
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