Targeting a Reticulocyte Binding Protein and Duffy Binding Protein to Inhibit Reticulocyte Invasion by Plasmodium vivax

Plasmodium vivax merozoite invasion is restricted to Duffy positive reticulocytes. Merozoite interaction with the Duffy antigen is mediated by the P. vivax Duffy binding protein (PvDBP). The receptor-binding domain of PvDBP maps to an N-terminal cysteine-rich region referred to as region II (PvDBPII...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Gupta, Sonal, Singh, Shailja, Popovici, Jean, Roesch, Camille, Shakri, Ahmed Rushdi, Guillotte-Blisnick, Micheline, Huon, Christèle, Menard, Didier, Chitnis, Chetan E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6043553/
https://ncbi.nlm.nih.gov/pubmed/30002416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28757-4
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