Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment

Gigaxonin (also known as KLHL16) is an E3 ligase adaptor protein that promotes the ubiquitination and degradation of intermediate filament (IF) proteins. Mutations in human gigaxonin cause the fatal neurodegenerative disease giant axonal neuropathy (GAN), in which IF proteins accumulate and aggregat...

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Publicado en:JCI Insight
Main Authors: Chen, Po-Han, Hu, Jimin, Wu, Jianli, Huynh, Duc T., Smith, Timothy J., Pan, Samuel, Bisnett, Brittany J., Smith, Alexander B., Lu, Annie, Condon, Brett M., Chi, Jen-Tsan, Boyce, Michael
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2020
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7030874/
https://ncbi.nlm.nih.gov/pubmed/31944090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127751
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