Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment

Gigaxonin (also known as KLHL16) is an E3 ligase adaptor protein that promotes the ubiquitination and degradation of intermediate filament (IF) proteins. Mutations in human gigaxonin cause the fatal neurodegenerative disease giant axonal neuropathy (GAN), in which IF proteins accumulate and aggregat...

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Publicat a:JCI Insight
Autors principals: Chen, Po-Han, Hu, Jimin, Wu, Jianli, Huynh, Duc T., Smith, Timothy J., Pan, Samuel, Bisnett, Brittany J., Smith, Alexander B., Lu, Annie, Condon, Brett M., Chi, Jen-Tsan, Boyce, Michael
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7030874/
https://ncbi.nlm.nih.gov/pubmed/31944090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127751
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