Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment

Gigaxonin (also known as KLHL16) is an E3 ligase adaptor protein that promotes the ubiquitination and degradation of intermediate filament (IF) proteins. Mutations in human gigaxonin cause the fatal neurodegenerative disease giant axonal neuropathy (GAN), in which IF proteins accumulate and aggregat...

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Библиографические подробности
Опубликовано в: :JCI Insight
Главные авторы: Chen, Po-Han, Hu, Jimin, Wu, Jianli, Huynh, Duc T., Smith, Timothy J., Pan, Samuel, Bisnett, Brittany J., Smith, Alexander B., Lu, Annie, Condon, Brett M., Chi, Jen-Tsan, Boyce, Michael
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2020
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7030874/
https://ncbi.nlm.nih.gov/pubmed/31944090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127751
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