Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment

Gigaxonin (also known as KLHL16) is an E3 ligase adaptor protein that promotes the ubiquitination and degradation of intermediate filament (IF) proteins. Mutations in human gigaxonin cause the fatal neurodegenerative disease giant axonal neuropathy (GAN), in which IF proteins accumulate and aggregat...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Chen, Po-Han, Hu, Jimin, Wu, Jianli, Huynh, Duc T., Smith, Timothy J., Pan, Samuel, Bisnett, Brittany J., Smith, Alexander B., Lu, Annie, Condon, Brett M., Chi, Jen-Tsan, Boyce, Michael
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7030874/
https://ncbi.nlm.nih.gov/pubmed/31944090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127751
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