The motif EXEXXXL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity

Many secretory proteins are activated by cleavage at specific sites. The proprotein convertases (PCs) form a family of nine secretory subtilisin-like serine proteases, seven of which cleave at specific basic residues within the trans-Golgi network, granules, or at the cell surface/endosomes. The sev...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Durand, Loreleï, Duval, Stéphanie, Evagelidis, Alexandra, Guillemot, Johann, Dianati, Vahid, Sikorska, Emilia, Schu, Peter, Day, Robert, Seidah, Nabil G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7029121/
https://ncbi.nlm.nih.gov/pubmed/31915245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011775
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