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Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning
The multispecific organic anion transporters, OAT1 (SLC22A6) and OAT3 (SLC22A8), the main kidney elimination pathways for many common drugs, are often considered to have largely-redundant roles. However, whereas examination of metabolomics data from Oat-knockout mice (Oat1 and Oat3KO) revealed consi...
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| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7029110/ https://ncbi.nlm.nih.gov/pubmed/31896576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010729 |
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