Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach

Statistical analysis was performed on physicochemical descriptors of ∼250 drugs known to interact with one or more SLC22 “drug” transporters (i.e., SLC22A6 or OAT1, SLC22A8 or OAT3, SLC22A1 or OCT1, and SLC22A2 or OCT2), followed by application of machine-learning methods and wet laboratory testing...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Liu, Henry C., Goldenberg, Anne, Chen, Yuchen, Lun, Christina, Wu, Wei, Bush, Kevin T., Balac, Natasha, Rodriguez, Paul, Abagyan, Ruben, Nigam, Sanjay K.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Metabolism, Transport, and Pharmacogenomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034704/
https://ncbi.nlm.nih.gov/pubmed/27488918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.232660
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