Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling

The endoplasmic reticulum (ER)-stress-induced cascade events are implicated in Parkinson’s disease (PD). The discovery of drug candidates to protect dopaminergic (DA) neurons from ER-stress-induced oxidative damage is important to resolve the pathological aspects of PD and modify its progress. In th...

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Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Ke, Minjing, Chong, Cheong-Meng, Zeng, Haitao, Huang, Miaodan, Huang, Zhijian, Zhang, Ke, Cen, Xiaotong, Lu, Jia-Hong, Yao, Xiaoli, Qin, Dajiang, Su, Huanxing
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028918/
https://ncbi.nlm.nih.gov/pubmed/32071291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2312-8
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