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Combined enzymatic degradation of proteoglycans and collagen significantly alters intratissue strains in articular cartilage during cyclic compression

As degenerative joint diseases such as osteoarthritis (OA) progress, the matrix constituents, particularly collagen fibrils and proteoglycans, become damaged, therefore deteriorating the tissue’s mechanical properties. This study aims to further the understanding of the effect of degradation of the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Mech Behav Biomed Mater
Hauptverfasser: Pastrama, Maria-Ioana, Ortiz, Ana Caxaido, Zevenbergen, Lianne, Famaey, Nele, Gsell, Willy, Neu, Corey P., Himmelreich, Uwe, Jonkers, Ilse
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028440/
https://ncbi.nlm.nih.gov/pubmed/31349141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmbbm.2019.05.040
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