Potent immunomodulatory effects of an anti-CEA-IL-2 immunocytokine on tumor therapy and effects of stereotactic radiation

While anti-CEA antibodies have no direct effect on CEA-positive tumors, they can be used to direct potent anti-tumor effects as an antibody-IL-2 fusion protein (immunocytokine, ICK), and at the same time reduce the toxicity of IL-2 as a single agent. Using a fusion protein of humanized anti-CEA with...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Kujawski, Maciej, Sherman, Mark, Hui, Susanta, Zuro, Darren, Lee, Wen-Hui, Yazaki, Paul, Sherman, Anakim, Szpikowska, Barbara, Chea, Junie, Lasiewski, Desiree, Poku, Kofi, Li, Harry, Colcher, David, Wong, Jeffrey, Shively, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028338/
https://ncbi.nlm.nih.gov/pubmed/32117587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1724052
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